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KMID : 0545119990090010050
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Journal of Microbiology and Biotechnology
1999 Volume.9 No. 1 p.50 ~ p.55
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Preparation of Nanoparticles in Drug Delivery System Using Guar Derivatives and Dialysis Method
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Na, Kun
Kim, Yu Eun/Lee, Ki Young
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Abstract
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to develop a new form of controlled release dosage for administering for indomethacin (IND), two formulations of IND-loaded nanoparticles were designed based on polysaccharide (guar) derivatives. Nanoparticles prepared by the dialysis method were characterzed with respect to morphology, size distribution, drug content. and in vitro drug release. Morphologieal studies by scanning electron microscopy (SEM) indicated that guar acetate (GA) nanoparticles were spherical in spherieal in shape and had a smooth surface. The particle site distributions of formulation Ⅰ (41 ㎎ of GA) and formulation Ⅱ (81 ㎎ of GA) were shown to be 250.78 L 185.13 nm and 718 145,90 nm in distilled water (20℃), respectively. the drug loading efficiencies of nanoparticles were approximately 26% and 31% for formulations Ⅰ and Ⅱ, respectively. The differential scanning calorimetry (DSC) results indicated that the INI) was perfectly distributed within GA nanoparticles. We also found, from the X-ray diffractometry analysis. that a decrease in the degree of crvstallinity of the drug occurred in the nanoparticles. No changes between the original IND and the released IND from GA nanoparticles were detected by FT-IR, Using guar acetate, it is possible to design nanoparticles which allow the controlled release of IND over an extended period of time.
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KEYWORD
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